http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013118393-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 |
| filingDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013118393-A |
| titleOfInvention | Quinoline derivatives, in particular 6,7-substituted with 1- (2-chloroquinolin-3-yl) -4-dimethylamino-2- (naphthalen-1-yl) -1-phenylbutane-2-oli, a method for their production FOR THE TREATMENT OF INFECTIOUS DISEASES OF MYCOBACTERIAL NATURE, IN PARTICULAR TUBERCULOSIS |
| abstract | 1. Quinoline derivatives, in particular 6,7-substituted 1- (2-chloroquinolin-3-yl) -4-dimethylamino-2- (naphthalen-1-yl) -1-phenylbutan-2-oles of the general formula (I) : where R is H, R + R is -O- (CH) -O-, where n = 1-2, which forms additional dioxane and 1,3-dioxolane rings, or their pharmaceutically acceptable salts with acids, having antimycobacterial activity. 2 . A method for producing compounds of formula (I) according to claim 1 by reacting substituted 2-chloro-3-alkarylquinolines and arylketones under the action of metalating agents. The method according to claim 2, characterized in that lithium diethylamide is used as the metallizing agent. The use of compounds according to claim 1 for the treatment of infectious diseases of mycobacterial nature, in particular tuberculosis. |
| priorityDate | 2013-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 17.