http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013111163-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2011-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013111163-A |
| titleOfInvention | METHOD IN VIVO CANCER VISUALIZATION |
| abstract | 1. A method for identifying and / or monitoring a cancer in a subject where said cancer is characterized by abnormal expression of peripheral benzodiazepine receptors (PBR), comprising the steps of: (a) administering to said subject an in vivo imaging agent of the formula I: wherein: R is C1-6alkyl or C-fluoroalkyl; R is hydrogen, hydroxy, halogen, cyano, Ci-Ci, Calkoxy, C-fluoro-ci or C-fluoroalkoxy; R and R are independently Ci-Ci, Saralkyl, or R and R together with the nitrogen atom to which they belong They are united to form a nitrogen-containing Salifaticheskoe ring optionally containing 1 additional heteroatom selected from nitrogen, oxygen and sulfur; Ypredstavlyaet is O, S, SO, SOili CH; and Y is CH, CH-CH, CH (CH) -CH or CH-CH-CH; and wherein said in vivo imaging agent of formula I contains an atom that is a radioisotope suitable for in vivo imaging; (b) allowing the binding of said in vivo imaging agent from step (a) with PBR expressed in said subject; (c) detecting signals emitted by a radioisotope contained in said in vivo associated imaging agent from step (b) using a suitable in vivo imaging method; (d) image generation expression reflecting the distribution and / or the number of these signals detected in stage (c); (e) determining the distribution and / or degree of PBR expression in the specified subject, where the specified expression directly correlates with the distribution and / or the number of these signals presented in the specified the image obtained in stage (g); and (e) use |
| priorityDate | 2010-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.