http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013105491-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 |
| filingDate | 2011-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013105491-A |
| titleOfInvention | COMPOSITIONS OF PEPTIDE RADIOACTIVE INDICATORS |
| abstract | 1. An imaging agent comprising a radiolabeled F cMet-binding cyclic peptide, wherein said cMet-binding cyclic peptide is an 18-30 mer cyclic peptide of formula I: wherein cMBP (cMet-binding cyclic peptide) has formula II: where Q is the amino acid sequence (SEQ-1): -Cys-X-Cys-X-Gly-Pro-Pro-X-Phe-Glu-Cys-Trp-Cys-Tyr-XXX-, where X is Asn, His or Tyr ; X is Gly, Ser, Thr, or Asn; X is Thr or Arg; X is Ala, Asp, Glu, Gly, or Ser; X is Ser or Thr; X is Asp or Glu; and all Cys are cysteine residues, so that residues a and b as well as c and d are cyclized to form two separate disulfide bonds; A and A 'independently represent any amino acid other than Cys, provided that at least one of A and A' is present and is Lys ; x and y are independently integers ranging from 0 to 13 and are selected so that the sum of x and y is from 1 to 13; Z is attached to the N-terminus of the cMBP and is H or M; Z is attached to the C-terminus of the cMBP and is OH, OB, or M, where B is a biocompatible cation; each M independently represents a group that inhibits metabolism, which is a biocompatible group that inhibits or suppresses the metabolism of cMBP peptide in vivo; where cMBP is labeled with F at the Lys residue of groups A or A'.2. An imaging agent according to claim 1, wherein the cMBP has the formula IIA: where z is an integer from 0 to 12, and the sum of x and z is from 0 to 12, and the cMBP contains only one Lys residue. An imaging agent according to claim 1 or claim 2, wherein Q contains the amino acid sequence of SEQ-2 or SEQ-3: Ser-Cys-X-Cys-X-Gly-Pro-Pro-X-Phe-Glu-Cys-Trp- Cys-Tyr-X- |
| priorityDate | 2010-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.