http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2013103794-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-56 |
| filingDate | 2011-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2013103794-A |
| titleOfInvention | NEW METHODS FOR PRODUCING Phenylcyclopropylamine Derivatives AND THEIR APPLICATION FOR PRODUCING TICAGRELOR |
| abstract | 1. A method of obtaining substituted derivatives of phenylcyclopropylamine of the formula II: or their stereochemically isomeric forms, or a mixture of stereochemically isomeric forms, or acid addition salts; where R, R, R, R, and R are each independently selected from a hydrogen atom and a halogen atom, provided that the benzene ring in Formula II is substituted with one or more halogen atoms, where the halogen atom is F, Cl, Br or I; comprising: a) reacting a halogen-substituted benzaldehyde compound of formula VIII: wherein R, R, R, R and R are as defined in formula II; with methyltriphenylphosphonium halide (Wittig reagent) of formula VII: where 'X' is a halogen atom selected from the group consisting of Cl, Br and I; in the presence of a first base in a first solvent to give a substituted styrene compound of formula VI: where R, R, R, R and R are as defined in formula II; b) the reaction of a compound of formula VI with a diazo ester compound of formula V: wherein “R” is an alkyl, cycloalkyl, aryl or aralkyl group; in the presence of a metal catalyst and a chiral ligand in a second solvent to obtain a substituted cyclopropanecarboxylate compound of the formula IV: or a stereochemically isomeric form thereof or a mixture of stereochemically isomeric forms where R, R, R, R, R and R are as defined in formula II; c ) hydrolysis of an ester compound of formula IV with an acid or a second base in a third solvent to obtain a substituted cyclopropanecarboxylic acid compound of formula III: or a stereochemically isomeric form thereof or a mixture of stereo chemically isomeric forms; d) optionally, purification of the compounds tsiklopropank |
| priorityDate | 2010-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 228.