http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012155786-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2010-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012155786-A |
| titleOfInvention | COMPOUND POSSESSING AN INHIBITING ACTION REGARDING PHOSPHODESTHESIS TYPE 5, AND METHOD FOR PRODUCING IT |
| abstract | 1. The compound of formula I or its pharmaceutically acceptable salts: where the chemical name of the compound of formula I is: 5- [2-ethoxyphenyl-5- (3,4,5-trimethylpiperazinyl) sulfonyl] -1-methyl-3-propyl- 1,6-dihydro-7H-pyrazolo [4,3-a] pyrimidin-7-ketone. 2. The compound is 5- [2-ethoxyphenyl-5- (3,4,5-trimethylpiperazinyl) sulfonyl] -1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-] pyrimidine -7-ketone citrate of formula II: .3. A process for preparing a compound of formula I comprising the following steps: (1) adding tetrahydrofuran to 2,6-dimethylpiperazine and ditretbutyl dicarbonate and reacting at room temperature, and then concentrating tetrahydrofuran until all is consumed, to give 3,5-dimethyl-1-tert β-butoxycarbonylpiperazine; (2) adding tetrahydrofuran, potassium carbonate and methyl iodide to 3,5-dimethyl-1-tert-butoxycarbonylpiperazine, obtained in turn in step (1), reacting at room temperature overnight, then filtering I and concentration, adding water and dichloromethane to the residue, washing with dichloromethane, combining the organic layer, washing with saturated brine, drying over anhydrous sodium sulfate, concentration, and column chromatography of the residue (methanol: dichloromethane = 1:20) to obtain 3.4.5 trimethyl-1-tert-butylcarbonylpiperazidine; (3) dissolving the 3,4,5-trimethyl-1-tert-butylcarbonylpiperazidine obtained in step (2) in dioxane, cooling and slowly dropwise adding a saturated solution of hydrochloric acid in dioxane with stirring at room temperature, and then evaporating the solvent under reduced pressure to obtain 1,2,6-trimethylpiperazine; (4) adding |
| priorityDate | 2010-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.