http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012155425-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 |
| filingDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012155425-A |
| titleOfInvention | METHOD FOR BIOCHEMICAL REACTIONS MANAGEMENT |
| abstract | 1. A method for controlling biochemical reactions in vitro and in vivo by acting on magnetic nanosuspension containing a bioactive macromolecule attached directly or via ligands to single-domain magnetic nanoparticles, an external low-intensity low-frequency alternating magnetic field that provides deformation and / or change in the conformation of bioactive macromolecules involved in the reaction .2. The method according to claim 1, characterized in that the bioactive macromolecule in magnetic nanosuspension is attached to two or more magnetic nanoparticles. The method according to claim 1, characterized in that the frequency of the magnetic field is chosen below a critical value equal to the reciprocal of the Brownian relaxation time of the magnetic moments of the nanoparticles in the liquid, which provides vibrational-rotational motion of the magnetic nanoparticles, causing the deformation and / or conformation of bioactive macromolecules. The method according to claim 1, characterized in that single-domain particles of magnetite (FeO ยท FeO) or other ferro- or ferrimagnets are used as magnetic nanoparticles. The method according to claim 1, characterized in that the magnetic nanoparticles are used with sizes smaller than those necessary for the transition to the single-domain state, but more critical, in which they transition to the superparamagnetic state. The method according to claim 1, characterized in that water or physiological saline or any biocompatible liquid is used as a solvent for the suspension. The method according to claim 1, characterized in that the polymer molecules of adjustable length and stiffness are used as a ligand. The method according to claim 1, characterized in that |
| priorityDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 14.