http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012148188-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2011-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012148188-A |
| titleOfInvention | THYENOPYRIDINE COMPOUND ETHERIAL DERIVATIVE CONTAINING A CYANO GROUP, METHOD FOR PRODUCING IT, ITS APPLICATION AND ITS COMPOSITION BASED ON IT |
| abstract | 1. A compound with a structure of formula I or a pharmaceutically acceptable salt thereof: wherein R is a cyano group. A compound with a structure of formula I or a pharmaceutically acceptable salt thereof according to claim 1, characterized in that said compound is selected from one of the following compounds: I-1: 5- (2-cyanobenzyl) -4,5,6,7-tetrahydrothieno [ 3,2-c] pyridin-2-yl acetate; I-2: 5- (3-cyanobenzyl) -4,5,6,7-tetrahydrothieno [3,2-c] pyridin-2-yl acetate; I-3: 5- (4-cyanobenzyl) -4,5,6,7-tetrahydrothieno [3,2-c] pyridin-2-yl acetate. 3. A compound with a structure of formula I or a pharmaceutically acceptable salt thereof according to claim 1, characterized in that said pharmaceutically acceptable salt comprises a salt formed by a compound of formula I and an inorganic acid or organic acid. A compound with a structure of formula I or a pharmaceutically acceptable salt thereof according to claim 3, characterized in that said pharmaceutically acceptable salt is selected from hydrochlorides, hydrobromides, hydroiodates, sulfates, hydrosulfates, phosphates, hydrophosphates, acetates, propionates, butyrates, lactates, mesylates, tosylates , maleates, benzoates, succinates, tartrates, citrates, fumarates, taurates, gluconates and amino acid salts of the compounds of formula I.5. A method for producing a compound with a structure of formula I or a pharmaceutically acceptable salt thereof according to any one of claims 1 to 4, characterized in that said method comprises the steps of: (1) reacting 5,6,7,7a-tetrahydrothieno hydrochloride [3,2- c] pyridin-2 (4H) -one with benzyl bromide or benzyl chloride substituted with cyano at -10 ° C to 105 ° C in the presence of triethylamine, pyridine, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, n |
| priorityDate | 2010-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.