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filingDate 2011-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2012146816-A
titleOfInvention TREATMENT OF DISEASES ASSOCIATED WITH AN APOPTIC RESPONSE PROTEIN PAR4 PROBLEM BY INHIBITING THE NATURAL ANTISMAL TRANSCRIPT OF THE PAR4 GENE
abstract 1. A method of modulating the function and / or expression of a PAR4 polynucleotide in a biological system, comprising: contacting said system with at least one antisense oligonucleotide of 5 to 30 nucleotides in length, wherein said at least one oligonucleotide has at least 50% identity a sequence with a sequence that is a reverse complement of the natural antisense sequence for the PAR4 polynucleotide; resulting in modulation of the function and / or expression of the PAR4.2 polynucleotide. A method for modulating the function and / or expression of a PAR4 polynucleotide in a biological system according to claim 1, comprising: contacting said biological system with at least one antisense oligonucleotide of 5 to 30 nucleotides in length, wherein said at least one oligonucleotide has at least 50% sequence identity with a sequence that is the reverse complement of a polynucleotide containing 5 to 30 consecutive nucleotides within nucleotides 1-354 of the natural anti semantic transcript corresponding to SEQ ID NO: 2; resulting in modulation of the function and / or expression of the PAR4.3 polynucleotide. A method of modulating the function and / or expression of a PAR4 polynucleotide in a patient’s cells or tissues in vivo or in vitro, comprising: contacting said cells or tissues with at least one antisense oligonucleotide of 5 to 30 nucleotides in length, said oligonucleotide having at least 50% sequence identity with antisense oligonucleotide for polynucleotide PAR
priorityDate 2010-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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