http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012145762-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012145762-A |
| titleOfInvention | METHOD FOR PRODUCING PARTICLES WITH REDUCED ELECTROSTATIC CHARGE |
| abstract | 1. A method of producing carrier particles for a dry powder composition for inhalation containing 1) a fraction of co-micronized particles made from a mixture of excipient and additive, said mixture having a mass median diameter (MMD) of less than 20 microns; 2) a fraction of coarse excipient particles having an MMD equal to or higher than 80 μm, comprising the following stages: a) co-micronizing the excipient particles and additive particles; b) adding and mixing the resulting micronized particles with coarse excipient particles; characterized in that co-micronized the particles from stage (a) are first conditioned under the influence of relative humidity of 50-75% at room temperature for a period of time ranging from 6 to 60 hours. 2. The method according to claim 1, wherein the co-micronized particles are conditioned under the influence of relative humidity of 55-70% for a period of time ranging from 24 to 48 hours. The method of claim 1, wherein the additive is magnesium stearate. The method of claim 1, wherein the excipient is alpha-lactose monohydrate. The method according to any one of claims 1 to 4, where the mass diameter of the coarse particles of the excipient is from 212 to 355 μm. A method of obtaining a dry powder composition for inhalation, comprising the step of mixing carrier particles according to any one of claims 1 to 5 with one or more active ingredients. The method of claim 6, wherein the active ingredient is a β2-adrenergic receptor agonist selected from the group consisting of salbutamol, terbutaline, phenoterol, salmeterol, formoterol, indacaterol, vilanterol and milveterol. The method according to claim 6, where the active ingredient |
| priorityDate | 2010-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.