| abstract |
1. Humanitariannet antibody to integrin α2 containing the variable region of the heavy chain, the variable region of the light chain, the constant region of the human light chain and the variant constant region of the heavy chain of human IgG1, while the variant constant region of the heavy chain of human IgG1 includes at least one amino acid modification relative to the constant region of the heavy chain of human IgG1 of the original humanized antibody to integrin α2 and this antibody exhibits a modified effector function compared with the original humanized antibody to integrin α2.2. The humanized integrin α2 antibody of claim 1, wherein the variant constant region of the human IgG1 heavy chain is an isotypic variant comprising CH1 from human IgG1, the hinge region from human IgG1, and the Fc region from human IgG3. The humanized integrin α2 antibody of claim 1, wherein the variant constant region of the human IgG1 heavy chain is an isotypic variant comprising CH1 from human IgG3, the hinge region from human IgG1, and the Fc region from human IgG3. The humanized integrin α2 antibody of claim 1, wherein the variant constant region of the human IgG1 heavy chain comprises a variant Fc region of human IgG1 that contains at least one amino acid modification relative to the Fc region of the human IgG of the original humanized antibody to integrin α2.5. The humanized anti-integrin α2 antibody of claim 4, wherein the amino acid modification comprises an amino acid substitution at an amino acid position selected from the group consisting of 269, 298 and 324, where the amino acid position of each member of the group is indicated using |