http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012137490-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2011-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012137490-A |
| titleOfInvention | ANTIBODIES WITH PH-DEPENDENT BINDING ANTIGEN |
| abstract | 1. An antibody with pH-dependent binding that specifically binds an antigen with a higher affinity at pH 7.4 than at pH 6.0, where the ratio of equilibrium dissociation constants (K) and / or the ratio of dissociation rate constants (k) at pH 6.0 / pH 7.4 and at 25 ° C is more than 2, 3, 4, 8, 10, 16 or more, or is in the range between 2, 3, 4, 8, 10, 16 or more, and where the antibody has a reduced clearance from plasma in vivo when interacting with the specified antigen compared to an antibody that does not exhibit pH-dependent binding, which has a similar affinity against the antigen at pH 7.4, but it has to be compared ratio Ki / or kpri pH 6.0 / pH 7.4 less than 2.2. An antibody with a pH-dependent binding that specifically binds an antigen with a higher affinity at pH 7.4 than at pH 6.0, where the Ki / ratio or k ratio at pH 6.0 / pH 7.4 and at 25 ° C is more than 2, 3, 4, 8, 10, 16 or more, or is in the range between 2, 3, 4, 8, 10, 16 or more, and where the antigen is both membrane-bound and soluble in vivo, and where the antibody mediates increased localization in the cell membrane receptor compared to an antibody that has a similar affinity for this antigen at pH 7.4, but has a comparative my ratio Ki / or kpri pH 6.0 / pH 7.4 less than 2.3. The antibody according to claim 1 or 2, where the antigen is not an interleukin-6.4 receptor. The antibody of claim 2, wherein the antigen is a soluble receptor that is a non-signaling trap receptor. The antibody of claim 2, wherein said pH-dependent antibody is a drug-antibody conjugate that mediates an antibody-dependent cell-mediated cyto |
| priorityDate | 2010-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.