http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012134838-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2012-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012134838-A |
| titleOfInvention | COMPOSITIONS OF PROCARIOTIC PHENYLALANINE-AMMONIA-LIAZA AND METHODS FOR TREATING CANCER USING SUCH COMPOSITIONS |
| abstract | 1. A pharmaceutical composition for treating phenylketonuria (PKU), comprising (a) an effective amount of an Anabaena variabilis phenylalanine ammonia lyase variant (AvPAL), wherein cysteine residues at positions 503 and 565 of said AvPAL variant are substituted with serine residues (SEQ ID NO: 11) and said AvPAL variant further comprises polyethylene glycol, and (b) a pharmaceutically acceptable carrier comprising a stabilizer, wherein the stabilizer is L-phenylalanine or a structural analogue thereof. 2. The pharmaceutical composition according to claim 1, wherein said stabilizer is selected from the group consisting of L-phenylalanine, trans-cinnamic acid and benzoic acid. The pharmaceutical composition of claim 2, wherein said stabilizer is L-phenylalanine. The pharmaceutical composition of claim 2, wherein said stabilizer is trans cinnamic acid. The pharmaceutical composition according to claim 2, wherein said stabilizer is benzoic acid. The pharmaceutical composition of claim 1, wherein the ratio of said AvPAL variant to polyethylene glycol is about 1: 3.7. The pharmaceutical composition of claim 6, wherein said stabilizer is selected from the group consisting of L-phenylalanine, trans-cinnamic acid and benzoic acid. The pharmaceutical composition of claim 7, wherein said stabilizer is L-phenylalanine. The pharmaceutical composition of claim 7, wherein said stabilizer is trans cinnamic acid. The pharmaceutical composition of claim 7, wherein said stabilizer is benzoic acid. A method of treating a subject suffering from cancer, comprising administering to the subject a therapeutically effective amount |
| priorityDate | 2007-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.