http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012130841-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-862 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-42 |
| filingDate | 2012-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012130841-A |
| titleOfInvention | BINDING ELEMENTS FOR THE IgE MOLECULE |
| abstract | 1. An isolated binding member specific for immunoglobulin E, where the binding member has an geometric mean IC50 for inhibiting the transmission of calcium signal induced by 25 ng / ml IgE in RBL-ER51 cells, less than 1 nM. 2. The isolated binder of claim 1, wherein the geometric mean IC50 for inhibiting calcium signal transmission is less than 0.1 nM. An isolated binding member specific for immunoglobulin E, where the binding member has an IC50 value for binding said binding member to serum immunoglobulin E, which is at least 10 times lower than for Xolair ™. 4. The insulated binder according to claim 3, wherein said binder has an IC50 value that is at least 50 times lower than for Xolair ™ .5. An isolated binding member specific for human immunoglobulin E comprising a CDR kit: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, where the CDR kit has 10 or fewer additions, substitutions, deletions and / or insertions from a plurality of CDRs in which: HCDR1 has the amino acid sequence of SEQ. ID NO: 103; HCDR2 has the amino acid sequence of SEQ. ID NO: 104; HCDR3 has the amino acid sequence of SEQ. ID NO: 105; LCDR1 has the amino acid sequence of SEQ. ID NO: 108; LCDR2 has the amino acid sequence of SEQ. ID NO: 109; LCDR3 has the amino acid sequence of SEQ. ID NO: 110.6. The isolated binding member specific for the human immunoglobulin E of claim 5, wherein the amino acid substitutions include 6 or less amino acid substitutions. An isolated binder comprising a set of CDRs: HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3, where HCDR3 includes: amino acid sequence S |
| priorityDate | 2007-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.