http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012129931-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 |
| filingDate | 2010-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012129931-A |
| titleOfInvention | RAPP-SUPPORTING THIAZOLIDINDIONES AND THEIR COMBINATIONS FOR TREATMENT OF NEURODEGENERATIVE DISEASES |
| abstract | 1. A method of treating or preventing a neurodegenerative disorder in a patient, comprising administering to a patient a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein each R and R are independently selected from H, halogen, an aliphatic group and alkoxy, where the aliphatic group or alkoxy is optionally substituted with 1-3 halogen atoms ; R'is H; R is H, halogen, hydroxy or an optionally substituted aliphatic group, -O-acyl, -O-aroyl, -O-heteroaroyl, -O (SO) NH, -O-CH (R) OC (O ) R, -O-CH (R) OP (O) (OR), -OP (O) (OR), or, where each R is optional and independent is substituted with C 1-6 alkyl, each R is independently C 1-6 alkyl, C 1-6 cycloalkyl or phenyl, each of which is optionally substituted, or R and R ′ together form oxo; R is H or optionally substituted C 1-6 alkyl; the ring A is phenyl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, each of which is substituted with an R group and an R group at any chemically possible position on ring A.2. The method according to claim 1, where the neurodegenerative disease includes Alzheimer's disease, Parkinson's disease, ALS, MS, UKN, or any combination thereof. The method according to claim 1, where R is H.4. The method according to claim 1, wherein R is H, methyl, methoxy, ethoxy, -O-isopropyl, -CF, -OCHF or -OCF. 5. The method of claim 1, wherein R is H, alkyl, halogen or alkoxy. 6. The method according to claim 5, wherein R is C1-6alkyl. The method of claim 1, wherein ring A is phenyl which is substituted with R and R groups at any chemically possible position of ring A.8. The method of claim 1, wherein ring A is optionally substituted pyridin-2-yl or optionally substituted pyridin-3-yl, any of which is substituted with R and R groups at any chemically possible position of ring A.9. The method of claim 7, wherein ring A is phenyl and � |
| priorityDate | 2009-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.