http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012129361-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 2010-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012129361-A |
| titleOfInvention | Pyrrolidine derivatives as NK-3 receptor antagonists |
| abstract | 1. The compound of formula I where R is hydrogen, halogen, cyano, lower alkyl or lower alkyl substituted with halogen; n is 1, 2 or 3, if n is 2 or 3, then R may be different; R is C-alkyl or C- cycloalkyl; R is a group where X is CH or N; R is hydrogen, —C (O) lower alkyl, —C (O) O lower alkyl, S (O) lower alkyl, —C (O) CHO lower alkyl, —C (O) —CH — CN, or is —C (O) cycloalkyl, cycloalkyl or —CH — cycloalkyl, where the cycloalkyl groups are optionally substituted with lower alkyl, —CH — O — lower alkyl, lower alkoxy, CF, halogen or cyano, or is —C (O) heterocycloalkyl or heterocycloalkyl, or is —C (O) heteroaryl, or is heteroaryl, or is— C (O) -aryl or aryl, where heterocycloalkyl, heteroaryl or aryl groups are optionally substituted with halogen, lower alkyl, = O, lower alkoxy, lower alkyl, substituted with halogen, lower alkyl, substituted with hydroxy, -C (O) -CH-N (di-lower alkyl), C (O) NH-lower alkyl, C (O) NH, -O-C (O) -lower alkyl, C (O) -lower alkyl, S (O) -lower alkyl scrap or cyano; R1 represents aryl which is optionally substituted with halogen, hydroxy, lower alkyl, lower alkyl, substituted with halogen, S (O) lower alkyl, cyano or lower alkoxy; or a pharmaceutically active salt thereof. 2. The compound of formula I according to claim 1, wherein R1 represents aryl substituted with halogen. The compounds of formula I according to claim 1, wherein the aryl is phenyl. 4. The compound of formula Ia according to claim 1, where R represents halogen; n represents 1, 2 or 3, if n represents 2 or 3, then halogens may vary; R represents C-alkyl and |
| priorityDate | 2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.