http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012124810-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198 |
| filingDate | 2010-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012124810-A |
| titleOfInvention | METHOD FOR PRODUCING F-18 LABORATED GLUTAMINE ACID DERIVATIVES |
| abstract | 1. A method for producing a compound of formula I which comprises the steps of: Step 1: Synthesizing a radiolabeled compound of formula III by reacting a compound of formula II with an F-18 fluorinating agent, Step 2: Cleavage of the protecting groups of a compound of formula III to obtain a compound of formula I, Step 3: Purification and preparing a compound of formula I wherein: X is selected from the group consisting of a) a bond, b) branched or unbranched (C2-C10) alkyl, c) branched or unbranched (C2-C10) alkoxy, d) branched or unbranched (C3-C10) alkenyl, e) p branched or unbranched (C3-C10) alkynyl, f) [(CH) -O] - (CH), Id) O - [(CH) -O] - (CH); n = 2-6, preferably n = 2 or 3; m = 1-3, preferably m = 1 or 2; o = 2-6, preferably o = 2 or 3; R and R are carboxyl protecting groups and where the carboxyl protecting group is independently selected from each other: branched or unbranched (C-C) alkyl, b) benzyl, c) allyl; R and R are independently selected from the group consisting of: a) hydrogen, b) an amino protecting group, or c) an NRR group is 1,3-dioxo-1 , 3-dihydro-2H-isoindol-2-yl (phthalimido) or an azido group; and encompassing their individual isomers, tautomers, diastereomers, enantiomers, mixtures and their suitable salts. 2. The method according to claim 1, wherein Stage 3 comprises solid phase extraction, preferably a cation exchange solid phase. The method according to claims 1 and / or 2, wherein the fluorination reaction [F] described in Step 1 is carried out at 0 ° C. to 160 ° C. 4. The method according to claims 1 and 2, wherein the [F] fluorinating agent used in Step 1 is formed from a base and [F] fluoride and the ratio of base to compound of formula II is greater than zero (> 0) and equal to or lower than 1 (≤1) .5. The method according |
| priorityDate | 2009-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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