http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012116880-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-186 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012116880-A |
| titleOfInvention | Processing of water-insoluble nanoparticles with hydrophilic conjugates of alpha-hydroxyphosphonic acid, modified with such a nanoparticle and their use as contrast agents |
| abstract | 1. A composition comprising: a water-insoluble nanoparticle to which at least one alpha hydroxyphosphonate moiety is attached, having the formula: wherein S is a spacer, L is a bond between S and R, R is a polymer hydrophilic moiety, m and p are 1-5, and n and o are 0-5.2. The composition of claim 1, wherein R is a polymer hydrophilic moiety based on ethylene oxide units. The composition according to claim 1 or 2, where the polymer hydrophilic groups are based on ethylene oxide, and where the poly (ethylene oxide) has a molecular weight equal to or less than 5000 Da. The composition of claim 1, wherein the nanoparticle is a superparamagnetic iron oxide based nanoparticle. The composition of claim 1, further comprising a pharmaceutically acceptable carrier or excipient. The composition according to claim 5 for use as an MRI contrast agent (magnetic resonance imaging) suitable for injection to a human subject. A method of using water-insoluble nanoparticles to which alpha-hydroxyphosphonate groups are attached in diagnostic imaging, comprising: administering said nanoparticles to a subject; ib) subjecting said subject to diagnostic imaging in which said nanoparticles act as a contrast agent. The method of claim 7, wherein the alpha hydroxyphosphonate moieties have the formula: wherein S is a spacer, L is a bond between S and R, R is a polymer hydrophilic moiety, m and p are 1-5, and n and o are 0 -5.9. The method of claim 8, wherein R is an ethylene-based polymer hydrophilic moiety� |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11389550-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2767430-C2 |
| priorityDate | 2009-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.