http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012107657-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate | 2010-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012107657-A |
| titleOfInvention | VACCINE AGAINST PCSK9 |
| abstract | 1. An immunogen containing at least one PCSK9 antigenic peptide or a functionally active variant thereof associated with an immunogenic carrier, wherein the PCSK9 antigenic peptide is selected from the group consisting of SEQ ID NO: 182, 183, 184, 185, 186, 187, 188 , 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213 , 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 317, 401, 402 and 403.2. An immunogen containing at least one PCSK9 antigenic peptide or a functionally active variant thereof associated with an immunogenic carrier, wherein the PCSK9 antigenic peptide is selected from the group consisting of SEQ ID NO: 46, 47, 48, 49, 50, 51, 52, 53 , 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78 , 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 314, 318 and 319.3. The immunogen according to claim 1 or 2, wherein said immunogenic carrier is selected from diphtheria toxoid, CRM197 or VLP (virus-like particle) selected from VLP HBcAg, HBsAg, Qbeta, PP7, PPV or norovirus. The immunogen according to claim 3, wherein said immunogenic carrier is selected from CRM197 or Qbeta VLP. The immunogen according to claim 4, where the PCSK9 antigenic peptide is selected from the group consisting of SEQ ID NO: 182-190.6. The immunogen according to claim 4, where the PCSK9 antigenic peptide is selected from the group consisting of SEQ ID NO: 67-73.7. The immunogen according to claim 4, wherein said PCSK9 antigenic peptide further comprises any of the following: - at its C-terminus, a linker having the formula (G) C, (G) SC or (G) K, where n is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 — at its N-terminus a linker having the formula C (G), CS (G) or K (G ), where n is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10, - at its C-terminus a linker having the formula (G) C, (G) SC or (G) K, where n is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10, and c |
| priorityDate | 2009-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.