http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2012107429-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 |
| filingDate | 2010-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2012107429-A |
| titleOfInvention | METHOD FOR PRODUCING PYRIMIDINYLACETONITRIL DERIVATIVES AND INTERMEDIATE DERIVATIVES FOR THEIR SYNTHESIS |
| abstract | 1. A process for producing a pyrimidinylacetonitrile derivative represented by the general formula (3) wherein X is a halogen atom, R is an alkoxymethyl group, and Me is a methyl group, characterized by carrying out a reaction in the presence of a base between a 2,4-dihalogenonitrobenzene derivative represented by the general formula ( 1) where X and R are the same as defined above, and 4,6-dimethoxy-2-cyanomethylpyrimidine represented by the formula (2) where Me is the same as defined above). The method for producing a pyrimidinylacetonitrile derivative according to claim 1, wherein the 2,4-dihalogenonitrobenzene derivative represented by the general formula (1) where X is a halogen atom and R is an alkoxymethyl group is obtained by alkylation of a 3,5-dihalo-2-nitrobenzoic acid derivative , represented by the general formula (4) where X is the same as defined above, in the presence of a base (method A) or by nitration of an alkyl 3,5-dihalogenbenzoate derivative represented by the general formula (5) where R' is an alkyl group and X is the same as defined above (method B) to give an alkyl 3,5-dihalo-2-nitrobenzoate derivative represented by the general formula (6) where X and R' are the same as defined above, followed by reduction of an alkyl 3,5-dihalo-2-nitrobenzoate derivative to give a 2,4-dihalo-6-hydroxymethylnitrobenzene derivative represented by the general formula (7) where X is the same as defined flax above, and by alkylation of the 2,4-dihalo-6-hydroxymethylnitrobenzene derivative in the presence of a base.3. |
| priorityDate | 2009-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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