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filingDate 2010-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2013-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2012103476-A
titleOfInvention HYDROCODONE CONJUGATES WITH BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBIC ACID, DRUGS, WAYS OF THEIR OBTAINING AND THEIR APPLICATION
abstract 1. A composition comprising at least one conjugate, wherein the conjugate comprises hydrocodone and at least one benzoic acid, a derivative thereof, a salt thereof, or a combination thereof. The composition according to claim 1, where at least one benzoic acid or derivative of benzoic acid has the following formula I: where X, Y and Z are independently selected from the group consisting of H, O, S, NH and - (CH) -; R, R and R are independently selected from the group consisting of H, alkyl, alkoxy, aryl, alkenyl, alkynyl, halogen atom, halogen substituted alkyl, alkylaryl, arylalkyl, heterocycle, arylalkoxy, cycloalkyl, cycloalkenyl and cycloalkynyl; o, p, q are independently selected from 0 or 1 ; and x denotes an integer ranging from 1 to 10.3. The composition of claim 1, wherein the at least one benzoic acid or benzoic acid derivative is aminobenzoate, hydroxybenzoate, amino hydroxybenzoate, a derivative thereof, or a combination thereof. The composition of claim 3, wherein the aminobenzoate is selected from the group consisting of anthranilic acid, 3-aminobenzoic acid, 4,5-dimethylanthranilic acid, N-methylanthranilic acid, N-acetylanthranilic acid, phenamic acids (e.g., tolfenamic acid, mefenamic acid, flufenamic acid ), 2,4-diaminobenzoic acid (2,4-DABA), 2-acetylamino-4-aminobenzoic acid, 4-acetylamino-2-aminobenzoic acid, 2,4-diacetylaminobenzoic acid, their derivatives and their combinations. 5. The composition of claim 3, wherein the hydroxybenzoate is selected from the group consisting of salicylic acid, acetylsalicylic acid (aspirin), 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 6-methylsalicylic acid, o, m, p-cresotinic acid, anacardic acids, 4 5-dimethylsalicylic acid, o, m, p-hydroxy-p
priorityDate 2009-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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