| abstract |
1. A compound of formula (): or a pharmaceutically acceptable form thereof, wherein: (i) each of R, R, and R independently is —H, C1-6alkyl or Cperhaloalkyl, R is a —LZ group, and Z is Caryl; (ii) each R, R. a heterocyclic fused ring, and R and R are independently —H, Calky or Cpergalogenalkil; or (iv) R and R are combined to form a C-carbocyclic or 3-14 membered heterocyclic spherically fused ring, and R and R are independently —H, C 1-6 alkyl or C 1 -haloalkyl; L is a covalent bond or a divalent C 1 hydrocarbon group, where one, two or three methylene units L is optionally and independently replaced by one or more oxygen, sulfur, or nitrogen atoms; G is —CN, —NO, —S (= O) R, —SOR, —SONRR, —POR, —POOR, —PONRR, - (C = O) R, - (C = O) OR, - (C = O) NRR, -Br, -I, -F, -Cl, -OR, -ONRR, -ONR (C = O) R, -ONRSOR , -ONRPOR, -ONRPOOR, -SR, -OSOR, -NRSOR, -OPOR, -OPOOR, -NRPOR, -NRPOOR, -OPONRR, -O ( C = O) R, -O (C = O) OR, -NRR, -NR (C = O) R, -NR (C = O) OR, -O (C = O) NRR, -NR (C = NR) NRR, -O (C = NR) NRR, -NR (C = NR) OR or - [N (R) R] X, where X is a counterion; wherein each R independently is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 2 carbocyclyl, Caryl, 3-14 membered heterocyclyl or 5-14 membered heteroaryl; each R bonded to a nitrogen atom independently represents an —H, C1-6alkyl or amino protecting group; or R and R are combined to form a 3-14 membered heterocyclic ring or a 5-14 membered heteroaryl ring; C 1-6 alkyl, Caryl, 3-14 membered heterocyclyl, 5-14 membered heteroaryl, C carboc |