http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011150787-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-906 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3356 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0836 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2010-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011150787-A |
| titleOfInvention | SiRNA CONJUGATE AND METHOD FOR ITS PRODUCTION |
| abstract | 1. The conjugate of siRNA and a polymer compound having the following structure: A-X-R-Y-B, where A and B independently represent a hydrophilic polymer or hydrophobic polymer compound; X and Y independently represent a single covalent bond or a covalent bond through an intermediate linker; and R represents siRNA. 2. A conjugate of siRNA and a polymer compound having the following structure: A-X-R, wherein A is a hydrophobic polymer compound; X is a single covalent bond or a covalent bond through an intermediate linker; and R represents siRNA. 3. The conjugate according to claim 1 or 2, wherein the siRNA (R) single strand comprises from 19 to 31 nucleotides. The conjugate according to claim 1 or 2, wherein the hydrophobic polymer compound (A) has a molecular weight of from 250 to 1000.5. The conjugate according to claim 4, wherein the hydrophobic polymer compound (A) is a C-C hydrocarbon or cholesterol. The conjugate according to claim 1 or 2, wherein the covalent bond (X, Y) is a non-cleavable bond or a cleavable bond. The conjugate of claim 6, wherein the non-cleavable bond is an amide bond or a phosphate bond. The conjugate of claim 6, wherein the cleavable bond is selected from a disulfide bond, an acid cleavable bond, an ester bond, an anhydride bond, a biodegradable bond, and a bond cleaved by an enzyme. The conjugate according to claim 1, wherein the hydrophilic polymer compound (A or B) is a non-ionic polymer compound having a molecular weight of from 1000 to 10,000. The conjugate of claim 9, wherein the hydrophilic polymer compound is selected from the group consisting of polyethylene glycol (PEG), polyvinylpyrrolidone and polyoxazoline. |
| priorityDate | 2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.