http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011149721-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-136 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 |
| filingDate | 2011-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011149721-A |
| titleOfInvention | COMBINATIONS OF THERAPEUTIC MEDICINES FOR THE TREATMENT OF CANCER |
| abstract | 1. A combination comprising (a) an mTOR inhibitor compound selected from the group consisting of rapamycin, 40-O-alkyl derivatives of rapamycin, 40-O-hydroxyalkyl derivatives of rapamycin, 40-O-alkoxyalkyl derivatives of rapamycin, 32-deoxy derivatives of rapamycin and 32 -hydroxy derivatives of rapamycin, 16-O-substituted derivatives of rapamycin, derivatives of rapamycin, acylated on the oxygen atom at position 40, derivatives of rapamycin substituted at position 40 with heterocyclyl, and 40-O-phosphate derivatives of rapamycin, and (b) one or more pharmaceuticals evticheski active substances selected from the group consisting of a steroid, an alkylating agent; antimetabolite; microtubule binding agent; phosphatidinylinositol-3-kinase inhibitor; platinum compound; polyamine synthesis inhibitor; tyrosine kinase family inhibitor SRC; topoisomerase inhibitor and their mixture. 2. The combination according to claim 1, in which one or more pharmaceutically active substances are selected from the group comprising prednisone, thiotepa; N1, N12-diethylspermine ยท 4HCl, 8-phenyl-2- (morpholin-4-yl) chromen-4-one, 3- (4-chlorophenyl) -1- (1,1-dimethylethyl) -1H-pyrazolo [3 , 4-d] pyrimidin-4-amine (9CI), cytarabine; cladribine; vindesine sulfate; carboplatin; idarubicin hydrochloride, imitoxantrone hydrochloride, and a mixture thereof. 3. The combination according to claim 1 or 2, wherein the mTOR inhibitor compound is selected from the group consisting of 40-O- (2-hydroxy) ethyl rapamycin, CCI779, ABT578 and AP23573.4. The combination according to claim 3, wherein the mTOR inhibitor is 40-O- (2-hydroxy) ethyl rapamycin. The combination according to claim 1 or 2, wherein the mTOR inhibitor is a compound of the formula wherein R is CH or C-Calkynyl, R is H or -CH-CH-OH and X is = O, (H, H) or (H, OH), provided that R is not denoted by |
| priorityDate | 2006-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.