http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011141208-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C241-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 |
| filingDate | 2010-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011141208-A |
| titleOfInvention | IMPROVED METHOD FOR PRODUCING DIPEPTIDYLPEPTIDASE-IV INHIBITOR AND INTERMEDIATE COMPOUND |
| abstract | 1. A method of obtaining an intermediate compound of a dipeptidyl peptidase-IV inhibitor represented by chemical formula 2, as shown in the following reaction scheme 1, comprising: (step a) preparing a compound represented by chemical formula 6 by opening an epoxy ring in a compound represented by chemical formula 5, using Grignard reagent; (step b) obtaining a compound represented by chemical formula 7 by reacting a compound represented by chemical formula 6 with sodium azide; (step c) obtain a compound represented by chemical formula 8 by reacting a compound represented by chemical formula 7 with triphenylphosphine; (step d) obtaining a compound represented by chemical formula 9 by opening the aziridine ring in a compound represented by chemical formula 8 using a cyan reagent ; and (step e) preparing a compound represented by chemical formula 2 by hydrolysis of a compound represented by chemical formula 9 using a base; [Reaction Scheme 1] (in the above Reaction Scheme 1, X is halogen and PG is a protecting group). 2. The method of claim 1, wherein the amine protecting group is selected from the group consisting of butoxycarbonyl (Boc), benzyloxycarbonyl (Cbz), 9-fluorenylmethoxycarbonyl (Fmoc), acetyl, benzoyl, and tosyl. A derivative of the compound represented by the following chemical formula 8, obtained by obtaining the compound represented by the chemical formula 2 as defined in claim 1: [Chemical formula 8] (in the above chemical formula 8, PG represents a protective group) .4. Etc |
| priorityDate | 2009-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.