| abstract |
1. The compound having the formula A-X-B, in which A denotes a peptide vector containing an amino acid sequence at least 70% identical to the sequence selected from the group consisting of SEQ ID NO: 1-105 and 107-114, or fragment; X is a linker; IV denotes a therapeutic peptide. 2. A compound according to claim 1, characterized in that the therapeutic peptide is selected from the group consisting of antimicrobial peptides or peptide antibiotics, gastrointestinal peptides, pancreatic peptides, peptide hormones, hypothalamic hormones, pituitary hormones and neuropeptides. 3. The compound according to claim 1, characterized in that A denotes a polypeptide that has an amino acid sequence at least 70% identical to the sequence selected from the group consisting of Angiopep-1 (SEQ ID NO: 67), Angiopep-2 (SEQ ID NO: 97), cys-Angiopep-2 (SEQ ID NO: 113) and Angiopep-2-cys (SEQ ID NO: 114). 4. A compound according to claim 3, characterized in that said sequence identity is at least 90%. A compound according to claim 4, characterized in that the polypeptide contains an amino acid sequence selected from the group consisting of Angiopep-1 (SEQ ID NO: 67), Angiopep-2 (SEQ ID NO: 97), cys-Angiopep-2 (SEQ ID NO: 113) and Angiopep-2-cys (SEQ ID NO: 114) .6. A compound according to claim 5, characterized in that said polypeptide consists of an amino acid sequence selected from the group consisting of Angiopep-1 (SEQ ID NO: 67), Angiopep-2 (SEQ ID NO: 97), cys-Angiopep-2 (SEQ ID NO: 113) and Angiopep-2-cys (SEQ ID NO: 114). 7. The compound according to any one of claims 1 to 6, characterized in that X has the formula: where n is an integer between 2 and 15; and either Y is a thiol group in A, Z is a primary amino group in B, or Y is a thiol group in B, and Z is a primary amine |