http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011121240-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2009-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011121240-A |
| titleOfInvention | METHOD FOR PRODUCING CHINAZOLE COMPOUNDS |
| abstract | 1. The method of obtaining the compounds of formula (IX): where: R and Roba are methyl or together form a cyclopropyl group; R and R are hydrogen; V, W, X, and Y are independently selected from the group consisting of: H, F, Cl, I, Br, CN, C1-6alkyl, Haloalkyl, Calkoxy, Haloalkoxy and Calkanoyl; and R 1 is H, C 1-6 alkyl or OH; comprising the steps of: (a) nitrating a compound of formula (X): to obtain a compound of formula (XI) :( b) reacting a compound of formula (XI) under reducing conditions to obtain a compound of formula (XII) :( c) reacting a compound of formula (XII) with an alkyl or aryl sulfonyl halide of formula RSOT and an organic base to produce a compound of formula (XIII): wherein: R is an optionally substituted C 1-6 alkyl group or an optionally substituted aryl group, each of which may be substituted when necessary wherever chemically possible, 1-3 substituents, which are independently selected from the group consisting of: Ci, Ci, haloalkyl, -SR, -OR, -NRR, -NO, SCF, halogen, -C (O) R, -CN, and —CF, where R and R are independently H or C 1-6 alkyl; and T is a halo; (d) reacting a compound of formula (XIII) with an organic base and a glycine derivative of formula (XIV) where R is a substituted, optionally C1-6 alkyl group or an aryl group, each of which may be substituted, if necessary, 1- 3 substituents that are independently selected from the group consisting of: Cialkyl, Ci-haloalkyl, -SR, -OR, -NRR, -NO, SCF, halogen, -C (O) R, -CN, and -CF, where R and R are independently H or C1-6alkyl; to give a compound of formula (XV): (e) a reaction of a compound of formula (XV) under reducing conditions with a floor HAND compound of formula (XVI) :( e) reacting a compound of formula (XVI) under conditions bromotsianir |
| priorityDate | 2008-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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