| abstract |
1. Compounds of the formula: wherein CR or N is; CR or N; R and R are independently selected from the group consisting of hydrogen, C-alkyl, halogen, cyano and C-alkoxy; R and R are independently selected from the group consisting of from hydrogen, C-alkyl, halogen, cyano, C-alkoxy, amino and C-alkylsulfanyl; R is selected from the group consisting of hydrogen, C-alkyl, halogen, C-alkoxy, cyano, C-cycloalkyl, N-heterocyclyl, five-membered heteroaryl and phenyl; R is selected from the group consisting of methyl, these la, isopropyl, difluoromethyl, trifluoromethyl, cyclopropyl and oxetanyl; or R and R together represent —X— (CRR) - and form part of a ring; where X is selected from the group consisting of -CRR-, O, S, C = O; R and R are independently selected from hydrogen or C-alkyl; R and R are independently selected from the group consisting of hydrogen, C-alkyl, C -alkoxycarbonyl, unsubstituted heterocyclyl and heterocyclyl substituted with one or two groups selected from C-alkyl or halogen, or R and R together with the C atom to which they are attached form a cyclopropyl or oxetanyl ring, or together form a = CH or = CF group; X is selected from the group NR; R and R are hydrogen; R is selected from the group consisting of h hydrogen, C-alkyl, halogen-C-alkyl, C-cycloalkyl, C-cycloalkyl-C-alkyl, heterocyclyl, heterocyclyl-C-alkyl, heteroaryl, heteroaryl-C-alkyl, carboxyl-C-alkyl, C-alkoxycarbonyl -C-alkyl, C-alkylcarbonyloxy-C-alkyl, phenyl, where phenyl is unsubstituted or substituted by carboxyl-C-alkyl or C-alkoxycarbonyl, phenylcarbonyl, where phenyl is unsubstituted or substituted by carboxyl-C-alkyl or C-a |