http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011115059-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-18 |
| filingDate | 2009-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011115059-A |
| titleOfInvention | SHORT WAY OF SYNTHESIS 1.6: 2,3-DIANHYDRO-B-D-MANNIPYRANOSE |
| abstract | 1. Method of obtaining compound (I):! ! characterized in that it contains the step of cyclization of the compound B:! ! in which R is an activator; in the presence of a base selected from ammonium hydroxides and inorganic bases. ! 2. A method according to claim 1, characterized in that the base is selected from ammonium hydroxide, sodium or potassium hydroxide and potassium, sodium or cesium carbonate. ! 3. A method according to claim 1 or 2, characterized in that the base is tetrabutylammonium hydroxide. ! 4. A method according to claim 1 or 2, characterized in that the base is cesium carbonate. ! 5. A method according to any one of claims 1 and 2, characterized in that the cyclization step is carried out in isopropanol, dichloromethane or acetonitrile, or in a binary mixture of these solvents. ! 6. The method according to claim 3, characterized in that the cyclization step is carried out in an isopropanol / dichloromethane mixture. ! 7. The method according to claim 6, characterized in that the cyclization step is carried out at a temperature of -10 ° C to 0 ° C. ! 8. The method according to claim 4, characterized in that the cyclization step is carried out in acetonitrile. ! 9. The method of claim 8, wherein the cyclization step is carried out at a temperature of about 40 ° C. ! 10. A method according to any one of claims 1 and 2, characterized in that the compound B is such that R is a tosyl, benzyl, benzenesulfonyl or p-halobenzylsulfonyl group. ! 11. The method according to any one of claims 1 and 2, characterized in that it includes:! connection activation stage A:! ! allowing to obtain compound B, which is described in item 1,! followed by the step of cyclizing compound B as defined in any one of claims 1-9. ! 12. The method according to claim 11, characterized in that the step of activating the compound A is carried out using tosyl-, benzyl-, benzenesulfonyl halide or p-halobenzylsul |
| priorityDate | 2008-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.