| abstract |
1. The compound of formula (I) !! where X is selected from = O, = S, = NH, = NOH and = NO-Me; ! A is selected from -C (= O) -, -S (= O) 2-, -C (= S) - and -P (= O) (R5) -, where R5 is selected from C1-6 alkyl, C1 -6-alkoxy and hydroxy; ! B is selected from a single chemical bond, - (CH2) 3-6-, -O-, and -O- (CH2) 2-5-; ! D is selected from a single chemical bond, —O—, —CR7R8— and —NR9, where R7, R8 and R9 are independently selected from hydrogen, optionally substituted C1-12 alkyl, optionally substituted C1-12 alkenyl, optionally substituted aryl substituted heterocyclyl; and optionally substituted heteroaryl; ! m is an integer of 0-12, and n is an integer of 0-12, where the sum of m + n is 1-20; ! p is an integer of 0-4; ! R1 is selected from optionally substituted heteroaryl; ! R2 is selected from hydrogen, optionally substituted C1-12 alkyl, optionally substituted C3-12 cycloalkyl, - [CH2CH2O] 1-10- (optionally substituted C1-6 alkyl), optionally substituted C1-12 alkenyl, optionally substituted aryl optionally substituted heterocyclyl; and optionally substituted heteroaryl; and R3 is selected from optionally substituted C1-12-alkyl, optionally substituted C3-12-cycloalkyl, - [CH2CH2O] 1-10- (optionally substituted C1-6-alkyl), optionally substituted C1-12-alkenyl, optionally substituted aryl, optionally substituted heterocyclyl; and optionally substituted heteroaryl; or R2 and R3 together with the atoms between them (i.e., -N-B-) form an optionally substituted N-containing heterocyclic or heteroaromatic ring; ! each of R4 and R4 * is independently selected from hydrogen, optionally substituted C1-12 alkyl and optionally substituted C1-12 alkenyl; ! provided that R1 is not optionally substituted thia� |