http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011109225-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-36 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2009-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011109225-A |
| titleOfInvention | MODIFIED BIOTIN-BINDING PROTEIN |
| abstract | 1. A modified biotin-binding protein comprising the amino acid sequence represented by SEQ ID NO: 2, an amino acid sequence having one to several amino acid mutations in the sequence represented by SEQ ID NO: 2, or an amino acid sequence identical to the sequence represented by SEQ ID NO: 2 , 80% or more, and having biotin-binding activity, where! one or more residues selected from the group consisting of:! 1) the arginine residue at position 104 of SEQ ID NO: 2; ! 2) a lysine residue at position 141 of SEQ ID NO: 2; ! 3) a lysine residue at position 26 of SEQ ID NO: 2; and! 4) the lysine residue at position 73 of SEQ ID NO: 2! replaced by an acidic amino acid residue or a neutral amino acid residue. ! 2. The modified biotin-binding protein according to claim 1, where the amino acid residue selected from 1) to 4) is replaced by an amino acid residue having a hydrophobicity index of 2 or less. ! 3. The modified biotin-binding protein according to claim 1, wherein 1) the arginine residue at position 104 of SEQ ID NO: 2 and / or 2) the lysine residue at position 141 of SEQ ID NO: 2 is replaced by an acidic amino acid residue or a neutral amino acid residue. ! 4. The modified biotin-binding protein according to claim 3, where 1) the arginine residue at position 104 of SEQ ID NO: 2 and / or 2) the lysine residue at position 141 of SEQ ID NO: 2 is replaced by an acidic amino acid residue. ! 5. The modified biotin-binding protein according to claim 3 or 4, where 1) the arginine residue at position 104 of SEQ ID NO: 2 and / or 2) the lysine residue at position 141 of SEQ ID NO: 2 is replaced by a glutamic acid residue. ! 6. The modified biotin-binding protein according to any one of claims 1 to 4, wherein the aspartic acid residue at position 40 of SEQ ID NO: 2 is replaced by an Asp |
| priorityDate | 2008-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.