| abstract |
1. A binding protein capable of binding prostoglandin E2 (PGE2) and at least one other antigen. ! 2. The binding protein according to claim 1, containing! (i) a polypeptide chain containing VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the heavy chain; ! VD2 is a second heavy chain variable domain; ! C represents a constant domain of the heavy chain; ! X1 is a linker, provided that it is not CH1; ! X2 is an Fc region; and! n is 0 or 1; ! (ii) a polypeptide chain containing VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the light chain; ! VD2 is a second light chain variable domain; ! C represents a constant domain of the light chain; ! X1 is a linker, provided that it is not CH1; ! X2 does not contain an Fc region; and! n is 0 or 1; ! (iii) the first and second polypeptide chains, where the specified first polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the heavy chain; ! VD2 is a second heavy chain variable domain; ! C represents a constant domain of the heavy chain; ! X1 is a linker, provided that it is not CH1; and! X2 is an Fc region; and! n is 0 or 1; ! and where the specified second polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the light chain; ! VD2 is a second light chain variable domain; ! C represents a constant domain of the light chain; ! X1 is a linker, provided that it is not CH1; ! X2 does not contain an Fc region; and! n is 0 or 1; or ! (iv) four polypeptide chains, where two poly |