http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2011101572-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00 |
| filingDate | 2009-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2011101572-A |
| titleOfInvention | METHOD FOR PRODUCING COMPOUNDS INHIBITING RO-KINASE |
| abstract | 1. A method of obtaining a compound of formula VII, comprising the steps of:! (a) reacting a compound of formula I, a compound of formula II, an acid having a pKa <5, with a reducing agent to obtain a compound of formula III; ! ! where Pg represents a protective group; ! n1 is 1 or 2; ! n2 is 1, 2 or 3; ! provided that in the case when n1 is 2, n2 is 2 or 3; and! R1, R2, R3, R4, R5 and R6 independently represent hydrogen, halogen, alkyl, alkenyl, alkynyl, amino, alkylamino, alkenylamino, alkynylamino, hydroxyl, alkoxy, alkenoxy or alkynoxy; ! (b) reacting a compound of formula III with an acid chiral resolving agent to obtain a diastereomeric salt represented by formula IV; ! ! (c) reacting the diastereomeric salt with an aqueous solution of a base to remove an acid chiral resolving agent and then removing the protecting group under deprotection conditions to give a compound of formula V; ! ! (d) reacting a compound of formula V with a compound of formula VI to form a compound of formula VII; ! ! where R1-R6, n1 and n2 are as defined above; ! A represents aryl or heteroaryl; ! X represents from 0 to 5 substituents on A and is selected from the group consisting of: hydroxy, oxo, nitro, methoxy, ethoxy, alkoxy, substituted alkoxy, trifluoromethoxy, haloalkoxy, fluoro, chloro, bromo, iodo, methyl, ethyl, propyl, butyl, alkyl, alkenyl, alkynyl, substituted alkyl, trifluoromethyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, thio, alkylthio, acyl, carboxy, alkoxycarbonyl, carboxamido, substituted carboxamido, alkylsulfonyl, substituted-sulfonylamino-sulfonylamino-sulfonylamido amino, al |
| priorityDate | 2008-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.