| abstract |
1. The compound of formula (I) !! Formula I! its pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers, where! T represents N, U represents N, X represents CR3 and Y represents N; or ! T represents CR6, U represents N, X represents CR3 and Y represents N; or ! T represents N, U represents CR4, X represents CR3 and Y represents N; or ! T represents CR6, U represents CR4, X represents CR3 and Y represents N; or ! T represents CR6, U represents N, X represents NR3 and Y represents C; or ! T represents O, U represents N, X represents CR3 and Y represents C; or ! T represents NR6, U represents N, X represents CR3 and Y represents C; or ! T represents CR6, U represents CR4, X represents NR3 and Y represents C; or ! T represents S, U represents N, X represents CR3 and Y represents C; ! R1, R2 and R5 each independently represents hydrogen, deuterium, —N (Ra) (Rb), halogen, —ORa, —SRa, —S (O) Ra, —S (O) 2Ra, —NO2, —C ( O) ORa, -CN, -C (O) N (Ra) (Rb), -N (Ra) C (O) (Rb), -C (O) Ra, -C (OH) RaRb, -N ( Ra) S (O) 2-Rb, -S (O) 2N (Ra) (Rb), -CF3, -OCF3, optionally substituted (C1-C6) alkyl, optionally substituted (C2-C6) alkenyl, optionally substituted ( C2-C6) alkynyl, optionally substituted (C3-C10) cycloalkyl, optionally substituted (C1-C10) heteroaryl, optionally substituted (C1-C10) heterocyclyl or optionally substituted (C6-C10) aryl; ! where in the moiety containing —N (Ra) (Rb), nitrogen, Ra and Rb can form a ring such that —N (Ra) (Rb) is an optionally substituted (C2-C10) heterocyclyl or neo |