http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010151857-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21021 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745 |
| filingDate | 2009-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010151857-A |
| titleOfInvention | METHOD FOR MONITORING REACTION OF POLYPEPTIDE MODIFICATION |
| abstract | 1. A method for activating a serine protease coagulation factor, comprising the steps of:! (a) measuring the initial concentration of a serine protease coagulation factor; ! (b) measuring the initial proportion of activated serine protease coagulation factor; ! (c) calculate the reaction time of activation of the serine-protease coagulation factor by correlating the values measured at each of stages (a) and (b) with the value of the required proportion of activated serine protease coagulation factor; and! (d) carry out the activation reaction of the serine protease coagulation factor during the time calculated in stage (c); ! (e) complete the reaction after the reaction time calculated in step (c). ! 2. The method according to claim 1, where the reaction time, T, in step (c) is calculated in accordance with formula (I): !! where "akt" refers to the required fraction of cleavable polypeptide, "akt0" refers to the initial fraction of cleavable polypeptide measured in step (b), "F0" refers to the initial concentration of the polypeptide (in g / l) measured in step (a), k (T) refers to the reaction constant for a given reaction (in l / g / min), as a function of temperature, T, and xb refers to the mole fraction. ! 3. The method according to claim 2, where k (T) is a polynomial or spline. ! 4. The method according to claim 1, where the correlation described in stage (C) is calculated in accordance with formula (II):! ! where akt, akt0, k, xb and F0 are as defined in claim 2, and k is the reaction constant. ! 5. The method according to claim 4, where k = 0.29. ! 6. The method according to claim 1, where xb = 1. ! 7. A method for preventing the cleavage of activated serine protease coagulation factor, comprising the steps of:! (a) measure the initial concentration |
| priorityDate | 2008-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.