http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010147934-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-248 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-248 |
| filingDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010147934-A |
| titleOfInvention | METHOD OF Glycosidation of Colchicine and Thiocolchicine |
| abstract | 1. A method of obtaining compounds having the formula I:! Formula I! where R1 is methoxy or methylthio; ! R2 is an O-glycosyloxy residue; ! comprising the interaction of peracetylated glucose with a compound having the formula II:! Formula II! where R1 is as defined above, followed by removal of the protective groups from the glycosyl fragment. ! 2. The method according to claim 1, wherein said peracetylated glycose or D- or L-rows are protected by ester groups. ! 3. The method according to claims 1 and 2, in which these protective groups are cleaved by hydrolysis in an alkaline environment. ! 4. The method according to claims 1 and 2, in which these protective groups are cleaved through nucleophilic displacement by interaction with an amine. ! 5. The method according to claim 1, in which the interaction is carried out in a solvent selected from the group consisting of acetonitrile, nitromethane, halogenated hydrocarbons and mixtures thereof. ! 6. The method according to claim 1, in which the interaction is carried out in the presence of a Lewis acid. ! 7. The method according to claim 6, in which the Lewis acid is boron trifluoride. ! 8. The method according to claim 1, in which the interaction is carried out in the presence of an organic base. ! 9. The method of claim 8, wherein said base is 1,1,3,3-tetramethylguanidine. |
| priorityDate | 2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.