| abstract |
1. The compound of formula (I) !! and its pharmaceutically acceptable salts,! where the dashed line represents, if necessary, an additional chemical bond; ! n is 0 or an integer from 1 to 4; ! R1 represents hydrogen; C1-C6 alkyl optionally substituted with cycloalkyl, aryl or heteroaryl; (CO) R3; (SO2) R4; cycloalkyl; aryl or heteroaryl; ! R2 is C1-C6 alkyl optionally substituted with aryl or heteroaryl; aryl; heteroaryl or (CO) R5; ! X represents CH2, oxygen or NR6; ! Y represents a chemical bond, CHR7 or NR8; ! Z represents oxygen, CR9R10 or C = R11; ! R3 is C1-C6 alkyl optionally substituted with aryl or heteroaryl; aryl; heteroaryl; O-C1-C6 alkyl optionally substituted with aryl; O-aryl or NR12R13; ! R4 is C1-C6 alkyl optionally substituted with aryl or heteroaryl; aryl or heteroaryl; ! R5 is OH, C1-C6 alkyl, O-C1-C6 alkyl or NR14R15; ! R6 is hydrogen, C1-C6 alkyl optionally substituted with aryl or heteroaryl; ! R7 is hydrogen or is absent when said additional chemical bond is present; ! R8 is hydrogen, C1-C6 alkyl optionally substituted with aryl or heteroaryl; ! R9 is hydrogen or is absent when said additional chemical bond is present; ! R10 represents hydrogen, hydroxyl, C1-C6 alkoxy, C1-C6 acylamino; ! R11 represents oxygen, sulfur or NOR16; ! R12 is hydrogen, C1-C6 alkyl optionally substituted with aryl or heteroaryl; aryl or heteroaryl; ! R13 represents hydrogen; C1-C6 alkyl, if necessary |