http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010141481-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate | 2009-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010141481-A |
| titleOfInvention | STABILIZED AS PROTEASES Acylated ANSULIN ANALOGUES |
| abstract | 1. Acylated insulin stabilized with respect to proteases, where stabilized with respect to proteases, insulin formally consists of insulin not stabilized with respect to proteases (parental insulin), in which at least one hydrophobic amino acid has been replaced by hydrophilic amino acids, and where the indicated replacement is within or in close proximity to one or more sites for protease cleavage of insulin (parental insulin) not stabilized with respect to proteases, and where such protease-stabilized insulin also possibly contains one or more additional mutations, provided that there is only one lysine residue in the stabilized insulin, and where the acyl moiety is attached to the lysine residue or at the N-terminal position in the protease-stabilized insulin . ! 2. The acylated protease-stabilized insulin according to claim 1, wherein at least two hydrophobic amino acids in the non-protease-stabilized insulin have been replaced by hydrophilic amino acids. ! 3. The acylated protease-stabilized insulin according to claim 1, wherein the acyl moiety is attached to the lysine residue in the protease-stabilized insulin. ! 4. The acylated protease-stabilized insulin according to claim 1, wherein the acyl moiety is attached to the amino group of the N-terminal residue of the A chain in the protease-stabilized insulin. ! 5. The acylated insulin stabilized with respect to proteases according to claim 1, where it is stabilized with respect to prot |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2684456-C2 |
| priorityDate | 2008-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.