http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010135196-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-32 |
| filingDate | 2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010135196-A |
| titleOfInvention | METHOD FOR PRODUCING 6-fluoro-1,2-dihydro-2-oxo-3n-indol-3-ylidene derivative |
| abstract | 1. The method of obtaining 4 - [(Z) - [[4 - [(dimethylamino) methyl] phenyl] amino] (6-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl] benzenepropanoic acid represented by Formula I! ! including stages:! (a) interactions of a compound of the formula! ! from ! (i) a compound of the formula! ! or with ! (ii) a compound of the formula! ! and! (b) subsequent deesterification of the ethyl ester group of propanoic acid,! in which the removal of the acetyl group attached to the lactam group in the compound of the formula! ! in reaction (ii) is carried out after stage (a),! and in which reaction (a) (i) or (a) (ii) is carried out in the presence of a mixture of reactants and solvents selected from:! - hexamethyldisilazane and n-toluenesulfonic acid monohydrate in the presence of triethylamine; ! - hexamethyldisilazane and n-toluenesulfonic acid monohydrate in the presence of pyridine; ! - hexamethyldisilazane and benzenesulfonic acid in the presence of triethylamine; ! - hexamethyldisilazane and benzenesulfonic acid in the presence of pyridine; ! - hexamethyldisilazane and trimethylsilyl chloride; ! - N, O-bis (trimethylsilyl) acetamide and pyridine; ! - trimethylsilyl imidazolid and pyridine. ! 2. The method of obtaining 4 - [(Z) - [[4 - [(dimethylamino) methyl] phenyl] amino] (6-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl] benzenepropanoic acid according to claim 1, comprising the steps of:! (a) interactions of a compound of the formula! ! with the compound of the formula! ! and! (b) subsequent deesterification of the ethyl ester group of propanoic acid,! in which the removal of the acetyl group attached to the lactam group in the compound of the formula! ! carried out after stage (a),! and in which reaction (a) is carried out in the presence of a mixture of reactants and solvents selected from:! - hexameter |
| priorityDate | 2008-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.