http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010134360-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2013 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 |
| filingDate | 2008-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010134360-A |
| titleOfInvention | COMBINATION OF AN ANTIBODIUM FUSED PROTEIN AGAINST EDB FIBRONECTIN-IL-2 AND THE MOLECULE BINDING WITH B-CELLS, B-CELL PREDATORS AND / OR THEIR MALIGNANT ANALOGUE |
| abstract | 1. A combination containing at least! i) a fusion protein containing an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and! ii) a molecule that binds to B cells, precursors of B cells and / or their malignant analogue; or a fusion protein comprising an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and a molecule specifically binding to CD20; or ! iii) a fusion protein containing an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and a molecule specifically binding to cells expressing CD20. ! 2. The combination according to claim 1, in which the molecule binds to B cells, precursors of B cells and / or their malignant analogue, specifically binds to CD20, CD23, CD22, CD40, CD80, HLA-DR or Hu1D10. ! 3. The combination according to claim 2, in which the molecule specifically binding to CD20, CD23, CD22, CD40 or CD80, is an antibody or antibody fragment or their fusion protein. ! 4. The combination according to claim 1, wherein the fusion protein has a fusion protein linker connecting the antibody part and the interleukin-2 part. !5. The combination according to claim 1, in which the part of the antibody specifically binds to the EDb domain of oncoembryonic fibronectin with subnanomolar or nanomolar affinity. ! 6. The combination according to claim 1, in which the part of the antibody contains at least one CDR sequence of the antibody L19. ! 7. The combination according to claim 1, in which the part of the antibody contains the sequence according to SEQ ID NO: 6-11. ! 8. The combination according to claim 1, in which the part of the antibody contains at least one heavy chain V according to SEQ ID NO: 1 or at least one light chain V according to SEQ ID NO: 2.! 9. The combination according to claim 1, in which the part is anti |
| priorityDate | 2008-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.