http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010133167-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2009-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010133167-A |
| titleOfInvention | ANALYSIS AND METHOD FOR EVALUATING SUSCEPTIBILITY AND INTEGRABILITY TO NK-CELLULAR MODULATION USING IMMUNOGLOBULIN THERAPY |
| abstract | 1. A method for determining the susceptibility of a patient to immunoglobulins in response to the treatment of a disease or the prevention of a disease with an NK cell disorder using immunoglobulins by determining the modulation of NK cells by these immunoglobulins. ! 2. The method according to claim 1, in which quantitative indicators of degranulation of natural killer cells are determined by an in vitro method. ! 3. The method of claim 1 or 2, wherein the natural killer cell degranulation positive patient is determined to be responsive to immunoglobulin treatment. ! 4. The method according to claim 1, wherein the assessment of the susceptibility of the patient to immunoglobulins in response to treatment of the disease or prevention of the disease using immunoglobulins is carried out by determining the level of the transcript, the level of the protein, or the level of the transcript and the protein level. ! 5. The method of claim 4, wherein the transcript level, protein level, or transcript level and protein level are quantified. ! 6. The method of claim 1, wherein the transcript level is determined by nucleic acid detection methods such as polymerase chain reaction (PCR). ! 7. The method of claim 1, wherein the protein level is determined using proteins released by natural killer cells and/or proteins expressed on the surface of natural killer cells. ! 8. The method of claim 1 wherein whole blood or blood cells are incubated in the presence of an activator in at least one assay with immunoglobulins and in at least one assay without immunoglobulins as a control, followed by measurement by expression of factors , indicating modulation of NK cells, |
| priorityDate | 2008-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.