http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010126842-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-205 |
| filingDate | 2008-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010126842-A |
| titleOfInvention | PIPERASIN DERIVATIVES AND THEIR APPLICATION AS LEPTIN RECEPTOR MODULATORS |
| abstract | 1. The compound of formula (I) !! or a pharmaceutically acceptable salt, solvate, hydrate, geometric isomer, tautomer, optical isomer or N-oxide thereof, where! X1 and X2 are each independently selected from N and CH; ! R1 is selected from hydrogen, C1-6 alkyl (unsubstituted or optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano and C1-6 alkoxy) and C1-6 acyl (unsubstituted or optionally substituted with one or more substituents independently selected from halogen, hydroxy and C1-6 alkoxy); ! R2 and R3 are independently selected from hydrogen, halogen, hydroxy, C1-6 alkyl (unsubstituted or optionally substituted with one or more substituents independently selected from halogen, hydroxy and C1-6 alkoxy) and C1-6 alkoxy (unsubstituted or optionally substituted by one or more substituents independently selected from halogen, hydroxy and C1-6 alkoxy); ! R4 is independently selected from hydrogen, halogen, hydroxy, cyano, nitro, CF3, C1-6 alkyl, and C1-6 alkoxy; ! Y represents O, C (R5A) (R5B) or N (R6); ! R5A and R5B each independently represent C1-4 alkyl or, together with the carbon atom to which they are attached, form a 3-6 membered cycloalkyl ring; ! R6 represents hydrogen or C1-4 alkyl; ! a, b and c, each independently, are 1, 2 or 3; ! d and e, each independently, are 0, 1 or 2; ! f is 0, 1, 2 or 3; and! g is 0, 1 or 2; ! provided that the compound is not selected from the group consisting of:! - 4- (2,4-dimethylphenyl) -N- (1-methyl-4-piperidinyl) -1-piperazinecarboxamide; ! - N- (1-methyl-4-piperidinyl) -4- (phenylmethyl) -1-piperidinecarboxamide; ! - 4-benzyl-N- [2- (4-methyl-1-piperazinyl) ethyl] -1-piperidinecarboxamide; ! - 4- (3-methylphenyl) -N- (1-methyl-4-piperidinyl) -1-piperazinecarboxamide; ! - 4- (4-chlorophenyl |
| priorityDate | 2007-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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