http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010114206-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2008-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010114206-A |
| titleOfInvention | N-OXIDES OF OCTAHYDROPYRROLO [3,4-b] PYRROL |
| abstract | 1. The compound of the formula:! ! or a pharmaceutically acceptable salt thereof, where! Z1 represents N or CH. ! 2. The compound according to claim 1, selected from the group consisting of:! (3aR, 5R, 6aR) -5-methyl-1- (4 '- (6-oxopyridazin-1 (6H) -yl) biphenyl-4-yl) octahydropyrrolo [3,4-b] pyrrole 5-oxide; ! (3aR, 5S, 6aR) -5-methyl-1- (4 '- (6-oxopyridazin-1 (6H) -yl) biphenyl-4-yl) octahydropyrrolo [3,4-b] pyrrole 5-oxide; ! (3aR, 5R, 6aR) -5-methyl-1- (4- (6- (6-oxopyridazin-1 (6H) -yl) pyridin-3-yl) phenyl) octahydropyrrolo [3,4-b] pyrrole 5 -oxide; and! (3aR, 5S, 6aR) -5-methyl-1- (4- (6- (6-oxopyridazin-1 (6H) -yl) pyridin-3-yl) phenyl) octahydropyrrolo [3,4-b] pyrrole 5 oxide. ! 3. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier. ! 4. A method of treating a mammal having a condition or disorder in which modulating the activity of the H3 histamine receptor has a therapeutic effect, wherein said method comprises administering to a subject having said condition or disorder or susceptible to said condition or disorder a therapeutically effective amount of a compound of formula (I ) according to claim 1. !5. The method of claim 4, wherein the condition or disorder is selected from the group consisting of Alzheimer's disease, asthma, allergic rhinitis, attention deficit hyperactivity disorder, attention deficit disorder, bipolar disorder, cognitive dysfunction, cognitive impairment in mental disorders, memory impairment, learning disabilities , dementia, skin carcinoma, drug abuse, diabetes, type II diabetes, depression, epilepsy, gastrointestinal upsets, inflammation, insulin resistance syndrome, desinges LSA after transmeridiannogo flight, medullary |
| priorityDate | 2007-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.