http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010113360-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2008-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010113360-A |
| titleOfInvention | IMPROVED LIPOSOMES AND THEIR APPLICATION |
| abstract | 1. A liposome containing at least one lipid bilayer surrounding the aqueous compartment, wherein said lipid bilayer contains at least one amphiphilic synthetic pyridinium derivative, in which the total amount of amphiphilic pyridinium derivative is from 2 to 25 mol% based on the total lipid content of the liposome. ! 2. The liposome according to claim 1, in which the total amount of amphiphilic pyridinium derivative is from 5 to 20 mol.%. ! 3. The liposome according to claim 2, in which the total amount of amphiphilic pyridinium derivative is 10-20 mol.%. ! 4. The liposome according to claim 1 or 2, having an outer diameter of from about 30 to about 300 nm, most preferably from 50 to 150 nm. ! 5. The liposome according to claim 1, in which at least one of said artificial amphiphilic pyridinium derivative is a SAINT molecule, preferably a SAINT molecule selected from those claimed in European patent EP0755924. ! 6. The liposome according to claim 4, containing SAINT-18 (1-methyl-4- (cis-9-dioleyl) methylpyridinium chloride) and / or SAINT-12 (1-methyl-4- (pentacosan-13-yl) pyridinium chloride) ! 7. The liposome according to claim 1, sterically stabilized, preferably by the inclusion of a monosialoganglioside (GM1) and / or poly (ethylene glycol) (PEG) derivative of a lipid in a lipid bilayer. ! 8. The liposome according to claim 1, containing on its surface at least one targeting agent capable of recognizing and binding to the surface molecule of an individual target cell or the intracellular compartment of the target cell. ! 9. The liposome of claim 8, wherein said targeting agents are specific for the surface of the target cell, which is not specialized for removing |
| priorityDate | 2007-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.