http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010102859-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B50-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2008-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010102859-A |
| titleOfInvention | IMPROVED METHODS FOR THE FORMATION OF DISULPHIDE LINKS |
| abstract | 1. A method for forming a disulfide bond, including: causing or enabling the attachment of a first (poly)peptide/protein to a second (poly)peptide/protein, where said attachment is caused by the formation of a disulfide bond between the first cysteine residue contained in the specified first (poly)peptide /protein, and the second cysteine residue contained in the specified second (poly)peptide/protein, where one of the specified (poly)peptides/proteins contains an amino acid having a pI above 8, which positively affects the reactivity of at least one of the specified cysteine leftovers. ! 2. The method of claim 1, wherein said amino acid having a pI greater than 8 is contained in said first (poly)peptide/protein. ! 3. The method of claim 1, wherein said amino acid having a pI greater than 8 is contained in said second (poly)peptide/protein. ! 4. The method of claim 2 or 3, wherein said amino acid having a pI greater than 8 is not present at the corresponding amino acid position in said wild-type (poly)peptide/protein. ! 5. The method of claim 4, wherein said amino acid having a pI greater than 8 has been artificially introduced. ! 6. The method of claim 1, wherein said amino acid having a pI greater than 8 is contained within ten amino acids adjacent to said cysteine residue in the same (poly)peptide/protein. ! 7. The method of claim 6, wherein said amino acid having a pI greater than 8 is contained within five amino acids adjacent to said cysteine residue in the same (poly)peptide/protein. ! 8. The method of claim 1, wherein said first cysteine residue is present at or near the N-terminus or C-terminus of said first (poly)peptide/protein. ! 9. The method according to claim 8, where the specified first cysteine |
| priorityDate | 2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.