| abstract |
The compound of formula (I)! ! where! R1, R13 and R2 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, halo, CF3 and CN; ! R3 and R4 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, halogen, OH, NR8R9, CF3, CN, aryl, heteroaryl, and CONR10R11, wherein said (C1-C6) is alkyl and said (C1 -C6) alkoxy are independently optionally substituted with 1, 2 or 3 groups independently selected from OH, (C1-C3) alkoxy, NR12R13, S (O) pR55 and halogen; ! R5 is selected from H, aryl, heteroaryl, heterocycloalkyl, (C3-C7) cycloalkyl, (CR14R15) mNR16R17, S (O) pR16, SO2NR16R17, CH2R16 and OR16; ! R6 is selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkyl, the group - (C3-C7) cycloalkyl- (C1-C6) alkyl, heteroaryl and aryl; wherein said (C1-C6) alkyl may optionally be substituted with halo or OH; ! R7 is selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkyl and aryl; ! or R6 and R7 together with the nitrogen atom to which they are attached form a 4-7 membered ring, optionally containing an additional heteroatom selected from NR18, S and O; ! R8 and R9 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, and (C3-C6) cycloalkyl; or R8 and R9 together with the nitrogen atom to which they are attached form a 4-7 membered ring, optionally containing an additional heteroatom selected from NR19, S and O; ! R14 and R15 are selected from H and (C1-C6) alkyl; or R14 and R15 together with the carbon atom to which they are attached form a carbonyl group (C = O); ! R16 is selected from H, aryl, (C3-C7) cycloalkyl and! where said (C3-C7) cycloalkyl may optionally be substituted with an aryl group; ! R17 is selected from H, (C1-C6) alkyl, aryl, heteroaryl, heterocycloalkyl and (C3-C7) cycloalkyl, wherein said (C1-C6) alkyl may optionally be substituted with 1, 2 or 3 groups independently selected from (C1- C6) alkoxy, (C3-C10) cycloalkyl, heterocycloalkyl, heteroaryl and NR20R21; ! R22 you |