| abstract |
1. A compound having the structure of formula (A)! ! as a single E- or Z-geometric isomer or a mixture of E- and Z-geometric isomers, as a tautomer or a mixture of tautomers, as a stereoisomer or as its pharmaceutically acceptable salt, hydrate, solvate, N-oxide or prodrug, where: ! R1 and R2 are the same or different and independently represent hydrogen or alkyl; ! R3, R4, R5 and R6 are the same or different with respect to each and independently represent hydrogen, halogen, nitro, —NH2, —NHR13, —N (R13) 2, —OR12, alkyl or fluoroalkyl; ! R7 and R8 are the same or different and independently represent hydrogen or alkyl; or R7 and R8, together with the carbon atom to which they are attached, form carbocyclyl or heterocyclyl; or R7 and R8 together form an imino; ! R9 is hydrogen, alkyl, carbocyclyl, heterocyclyl, —C (═O) R13, —SO2R13, —CO2R13, —CONH2, —CON (R13) 2, or —CON (H) R13; ! R10 represents hydrogen or alkyl; or R9 and R10, together with the nitrogen atom to which they are attached, form N-heterocyclyl; ! R11 represents alkyl, alkenyl, aryl, carbocyclyl, heteroaryl or heterocyclyl; ! each R12 is independently selected from hydrogen or alkyl; ! each R13 is independently selected from alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl; ! Z is a bond, Y or W-Y, where! W represents -C (R14) (R15) -, -O-, -S-, -S (= O) -, -S (= O) 2- or -N (R12) -; ! Y represents —C (R16) (R17) - or —C (R16) (R17) —C (R21) (R22) -; ! R14 and R15 are the same or different and independently represent hydrogen, halogen, alkyl, fluoroalkyl, —OR12, —NR18R19, carbocyclyl or heterocyclyl; or R14 and R15 together form oxo, imino, oxime or hydrazino; ! R16 and R17 are the same or different and not |