http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009133806-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate | 2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009133806-A |
| titleOfInvention | PEPTIDE AND NEPEPTIDE LIGANDS FOR IMMUNODETECTION OF THE UROTENZINE II RECEPTOR |
| abstract | 1. Cyclic peptides of the general formula (I) containing biotin or other fluorophore groups at the N-terminal position:! ! where X is selected from the group consisting of H, H-Asp, H-Phe, H-D-Phe, Gly, Gly-Gly, H-Glu-Thr-Pro-Asp and other spacers; ! Y is selected from the group consisting of OH, NH2, Val-OH, Val-NH2, Ile-OH and Ile-NH2; ! A and D, identical or different from each other, are selected from the group consisting of Phe, D-Phe, Tyr, D-Tyr, cyclohexyl alanine and cyclopentyl alanine; ! In selected from the group consisting of D-Trp, D- (α-Me) Trp, D-Trp (Me), D-Trp (CHO), D-Nal (1) and D-Nal (2); ! C is selected from the group consisting of Lys, Asp, Glu, Ora, Cit, Dap, Dab, and (p-amino) Phe; ! Z is Pen or Cys; ! Bio is a marker; ! or their pharmaceutically acceptable salts. ! 2. The cyclic peptides of claim 1, wherein said marker is selected from fluorophore agents and radioactive isotope radiomarkers. ! 3. The cyclic peptides of claim 2, wherein said fluorophore markers are selected from biotin, fluorescein isothiocyanate, rhodamine. ! 4. The cyclic peptides of claim 2, wherein said radiomarkers are selected from! 99 mTc, 124I, 110mI, 18F, 68Ga, 44Sc, 86Y. ! 5. The cyclic peptides of formula (I) according to claim 1-4, wherein C is selected from the group consisting of Lys, Orn and (p-amino) Phe. ! 6. The cyclic peptides of formula (I) according to claim 1, wherein B is D-Trp and C is Orn. ! 7. The cyclic peptides of formula (I) according to claim 1, in which X is H-Asp, Y is Val-OH, B is D-Trp, and C is Orn. ! 8. The cyclic peptides of formula (I) according to claim 1, selected from the following compounds:! Bio-Asp-cyclo [Pen-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO.1)! Bio-Asp-cyclo [Cys-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO.2)! Bio-Asp-cyclo [Pen-Phe-DTrp-Orn-Tyr-Cys] -Val-OH (SEQ ID NO.3)! Bio-Asp-cyclo [Pen-Phe-Trp-Lys-Tyr-Cys] -Val-NH2 (SEQ ID NO.4)! Bio-Asp-cyclo [Pen-Phe-DTrp-Orn-Tyr-Cys] -Val-NH2 (SEQ ID NO.5)! Bio-Glu-Thr-Pro-Asp-cyclo [Pen-Phe-Trp-Lys-Tyr-Cys] -Val-OH (SEQ ID NO.6)! Bio-Glu-Thr-Pro-Asp-cyclo [Pen-Phe-DTrp-Orn-Tyr-Cys] -Val-OH (SEQ ID NO.7)! Bio-Asp-cycle� |
| priorityDate | 2007-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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