http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009133793-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 |
| filingDate | 2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009133793-A |
| titleOfInvention | TREATMENT OF RESISTANT OR UNRELIABLE CANCER FORMS WITH 7-ETHYL-10-HYDROXYCAMPOTECINE CONJUGATES WITH MULTIPLE CHAIN BRANCHES |
| abstract | 1. A method for the treatment of resistant or immune cancer in a mammal, comprising:! administration to a mammal an effective amount of a compound of formula (I):! ! where R1, R2, R3 and R4 are independently OH or! ! where L represents a bifunctional linker; ! m = 0 or represents a positive integer; and! n represents a positive integer; ! provided that all R1, R2, R3 and R4 do not represent OH; ! or a pharmaceutically acceptable salt thereof. ! 2. The method according to claim 1, where the resistant or non-responsive cancer is selected from the group consisting of solid tumors, lymphomas, lung cancer, small cell lung cancer, acute lymphocytic leukemia (ALL), breast cancer, colorectal cancer, pancreatic cancer , glioblastoma, ovarian cancer and stomach cancer. ! 3. The method of claim 2, wherein the resistant or non-responsive cancer is colon and rectal cancer. ! 4. The method of claim 1, wherein the resistant or non-responsive cancer comprises a solid tumor. ! 5. The method of claim 1, wherein the resistant or non-responsive cancer comprises metastatic cancer. ! 6. The method according to claim 1, where the cancer is resistant or immune to treatment with camptothecin or an analogue of camptothecin. ! 7. The method according to claim 1, where the cancer is resistant or immune to the treatment of CPT-11. ! 8. The method according to claim 1, where the cancer is resistant or immune to treatment with camptothecin. ! 9. The method according to claim 1, where L is an amino acid residue or an amino acid derivative, and the amino acid derivative is selected from the group consisting of 2-aminoadipic acid, 3-aminoadipic acid, beta-alanine, beta-aminopropionic acid, 2-aminobutyric acid, 4-aminobutyric acid, piperide� |
| priorityDate | 2007-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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