http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009133259-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2008-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009133259-A |
| titleOfInvention | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS |
| abstract | 1. The compound of formula (1):! ! where Q represents O, S or a single bond; ! R1 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, heterocyclyl, arylC1-3alkyl, heteroarylC1-3alkyl, C3-7cycloalkylC1-3alkyl, C3-7cycloalkylC2-3alkenyl or C3-7cycloalkylC2-3alkynyl [each of which possibly substituted by 1, 2 or 3 substituents independently selected from C1-3 alkyl, hydroxy, halogen, oxo, cyano, trifluoromethyl, C1-3 alkoxy, C1-3 alkyl groups S (O) n- (where n is 0, 1, 2 or 3 ), R5CON (R5 ') -, (R5') (R5 '') NC (O) -, R5'C (O) O-, R5'OC (O) -, (R5 ') (R5' ') NC (O) N (R5```) -, R5SO2N (R5``) - and (R5 ') (R5``) NSO2- (where R5 is C1-3 alkyl, optionally substituted with 1, 2 or 3 substituents, selected from hydra xyl, halo or cyano; and! R5 'and R5' 'are independently selected from hydrogen and C1-3 alkyl optionally substituted with 1, 2 or 3 substituents independently selected from hydroxyl, halo, C1-3 alkoxy, carboxy and cyano, or R5' and R5 ″ together with the nitrogen atom to which they are attached form a 4-7 membered saturated ring)]; ! R2 is selected from heterocyclyl, groups C3-7 cycloalkyl (CH2) m- and C6-12 polycycloalkyl (CH2) m- (where m is 0, 1 or 2, and these rings are optionally substituted with 1, 2 or 3 substituents independently selected from R6) ; ! R3 is selected from hydrogen, C1-4alkylC3-5cycloalkyl and C3-5cycloalkylmethyl (each of which is optionally substituted with 1, 2 or 3 fluorine atoms); ! R 2 and R 3 together with the nitrogen atom to which they are attached form a saturated monocyclic, bicyclic or bridging ring system, possibly containing 1 or 2 additional ring heteroatoms selected from nitrogen, oxygen and sulfur, and which may be condensed with saturated, partially saturated or unsaturated monocyclic ring, while the resulting ring system in |
| priorityDate | 2007-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.