http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009129961-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
filingDate | 2008-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2011-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2009129961-A |
titleOfInvention | GLUCAGON ANALOGUES HAVING AN INCREASED SOLUBILITY IN BUFFERS WITH PHYSIOLOGICAL VALUE OF pH |
abstract | 1. The glucagon peptide comprising the sequence of SEQ ID NO: 33 or an analogue of the sequence of SEQ ID NO: 33, where the specified analogue differs from the sequence of SEQ ID NO: 33 with one to three amino acid substitutions, wherein said amino acid substitutions are located in one or more positions selected from positions 1, 2, 5, 7, 10, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21 and 24 of the analogue, provided that the specified glucagon peptide includes an amino acid at position 28 or 29, different from the amino acid found in the corresponding position of the sequence SEQ ID N O: 1, or includes an additional acidic amino acid attached to the carboxyl end of the peptide. ! 2. The glucagon peptide according to claim 1, comprising the sequence of SEQ ID NO: 34.! 3. The glucagon peptide according to claim 1, comprising the sequence of SEQ ID NO: 10.! 4. The glucagon peptide according to claim 1, comprising an analog of the sequence of SEQ ID NO: 34, where the amino acid at position 2 of the peptide of SEQ ID NO: 34 is different from serine. ! 5. The glucagon peptide according to claim 4, where the amino acid at position 2 of the peptide is selected from the group consisting of d-serine, alanine, glycine, n-methylserine and aminoisobutyric acid. ! 6. The glucagon peptide according to claim 1, comprising an analogue of the sequence of SEQ ID NO: 34, where the amino acid at position 1 of the peptide of SEQ ID NO: 34 is selected from the group consisting of d-histidine, desaminogistidine, hydroxyl histidine, acetyl histidine and homo histidine. ! 7. The glucagon peptide according to claim 1, further comprising a hydrophilic component covalently linked to position 16, 17, 21 or 24 of the glucagon peptide. ! 8. The glucagon peptide according to claim 7, where the specified hydrophilic component is a polyethylene glycol. ! 9. The glucagon peptide of claim 8, where the polyethylene glycol chain has a molecule |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2610175-C2 |
priorityDate | 2007-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.